The concomitant utilization of METHADOSE with all cytochrome P450 3A4, 2B6, 2C19, 2C9 or 2D6 inhibitors could cause an increase in methadone plasma concentrations, which could cause most likely fatal respiratory despair. On top of that, discontinuation of concomitantly utilized cytochrome P450 3A4, 2B6, 2C19, or 2C9 inducers may also end in a rise